In Vitro Antibacterial and Antifungal Activity and Computational Evaluation of Novel Indole Derivatives Containing 4-substituted Piperazine Moieties

ALTUNTAŞ T., Yilmaz N., Ece A., ALTANLAR N., ÖLGEN S.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.15, sa.10, ss.1079-1086, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 10
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1570180815666180109161948
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1079-1086
  • Anahtar Kelimeler: Antibacterial, antifungal, piperazine, indole, docking, ciprofloxacin, ACCURATE DOCKING, GLIDE, ANTIBACTERIAL
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Lack of specificity and occurence of resistance to current antibacterial and antifungal agents are major shortcomings for the treatment of microbial diseases. Finding novel antimicrobial agents is therefore highly needed to develop more potent drugs. Within this framework, several indole derivatives were designed and reported in the literature.