ORBITO-OCULAR GRANULOCYTIC SARCOMA (OOGS) AND ACUTE MYELOBLASTIC-LEUKEMIA (AML) WITH DUPLICATION OF PHILADELPHIA-CHROMOSOME

CAVDAR A., BOKESOY I., SUNGUROĞLU A., YAVUZ G., TANINDI S., GOZDASOGLU S., ...Daha Fazla

CANCER GENETICS AND CYTOGENETICS, cilt.69, sa.1, ss.38-40, 1993 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69 Sayı: 1
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1016/0165-4608(93)90110-8
  • Dergi Adı: CANCER GENETICS AND CYTOGENETICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.38-40
  • Ankara Üniversitesi Adresli: Evet

Özet

A 6-year-old Turkish boy with bilateral orbito-ocular granulocytic sarcoma and AML is described. Cytogenetic studies on peripheral blood disclosed an abnormal hyperdiploid population with a double Ph chromosome. Despite intensive chemotherapy, he achieved only partial remission. Repeated cytogenetic studies on bone marrow during relapse revealed the persistence of double Ph chromosome. The aggressive course and the short survival time of this patient, despite adequate chemo-radiotherapy, may be explained by the presence of the double Ph chromosome.