The role of tumor necrosis factor-alpha-308 G/A and transforming growth factor-beta 1-915 G/C polymorphisms in childhood idiopathic thrombocytopenic purpura

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Okulu E., İLERİ D. T., Culha V. K., Azik F. M., Egin Y., Uysal Z., ...Daha Fazla

TURKISH JOURNAL OF HEMATOLOGY, cilt.28, sa.3, ss.170-175, 2011 (SCI-Expanded, Scopus, TRDizin)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 28 Sayı: 3
• Basım Tarihi: 2011
• Doi Numarası: 10.5152/tjh.2011.50
• Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.170-175
• Anahtar Kelimeler: Idiopathic thrombocytopenic purpura, childhood, TNF-alpha, TGF-beta 1, polymorphism, BONE-MINERAL DENSITY, GENE POLYMORPHISM, GROWTH-FACTOR-BETA-1 GENE, ALPHA PROMOTER, ASSOCIATION, DISEASE, ACTIVATION, CHILDREN, WOMEN
• Ankara Üniversitesi Adresli: Evet

Özet

Objective: To increase our understanding of the etiology of idiopathic thrombocytopenic purpura (ITP) some cytokine gene polymorphisms were analyzed for susceptibility to the disease. The aim of this study was to investigate the role of tumor necrosis factor-alpha (TNF-alpha) -308 C/A and transforming growth factor-beta 1 (TGF-beta 1) -915 G/C polymorphisms in the development and clinical progression of childhood ITP.