Voltammetric investigation of Tamsulosin

Ozkan S. A., Uslu B., Aboul-Enein H.

Talanta, cilt.61, sa.2, ss.147-156, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 2
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0039-9140(03)00248-0
  • Dergi Adı: Talanta
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.147-156
  • Anahtar Kelimeler: tamsulosin HCl, determination, modified release capsules, voltammetric methods, PERFORMANCE LIQUID-CHROMATOGRAPHY, HUMAN PLASMA, DIFFERENTIAL-PULSE, RADIORECEPTOR ASSAY, MASS-SPECTROMETRY, SENSITIVE METHOD, URINE, ELECTRODES
  • Ankara Üniversitesi Adresli: Evet

Özet

The electrooxidative behavior and determination of Tamsulosin HCl (TAM), one of the α1-adrenoceptor antagonist, on a glassy carbon disc electrode were investigated for the first time by using cyclic, linear sweep, differential pulse (DPV) and square wave voltammetry (SWV). TAM showed an irreversible oxidation behavior at all pH values and buffers studied. From the electrochemical response, the main oxidation step was found to be related to the methoxy group on the phenyl ring. DPV and SWV were used to generate peak current versus concentration curves for TAM. A linear response was obtained in the range comprised between 2 × 10-6 and 4 × 10 -4 M for both techniques with detection limit of 3.34 × 10 -7 M for DPV and 2.45 × 10-7 M for SWV. The methods were proposed for the determination of TAM in dosage forms adopting both DPV and SWV modes. The methods were extended to the in vitro determination of TAM in spiked serum samples. © 2003 Elsevier B.V. All rights reserved.