Antioxidant and Antifungal Properties of Benzimidazole Derivatives

KUŞ C., Sozudonmez F., EKE B., ÇOBAN T.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, cilt.65, sa.9-10, ss.537-542, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 65 Sayı: 9-10
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1515/znc-2010-9-1002
  • Dergi Adı: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.537-542
  • Anahtar Kelimeler: Benzimidazole, Lipid Peroxidation, Superoxide Anion, LIPID PEROXIDE FORMATION, CHROMATOGRAPHY MASS-SPECTROMETRY, ASSAY, FLUCONAZOLE, OXIDATION, MEMBRANE, OXIDANTS, INCREASE, CANCER
  • Ankara Üniversitesi Adresli: Evet

Özet

Antioxidant and radical scavenging properties of a series of 2-[4-(substituted piperazin-/piperidin-1-ylcarbonyl)phenyl]-1H-benzimidazole derivatives were examined. Free radical scavenging properties of compounds 11-30 and 33 were evaluated for the stable free radical 2,2-diphenyl-1 -picrylhydrazyl (DPPH) and superoxide anion radical. In addition the inhibitory effects on the NADPH-dependent lipid peroxidation levels were determined by measuring the formation of 2-thiobarbituric acid reactive substances (TBARS) using rat liver microsomes. Compound 33 which has a p-fluorobenzyl substitutent at position 1 exhibited the strongest inhibition (83%) of lipid peroxidation at a concentration of 10(-3) M, while the nonsubstituted analogue 13 caused 57% inhibition. This result is fairly consistent with the antimicrobial activity results against both Staphylococcus aureus and Candida albicans.