Effect of inhibition of ornithine decarboxylase activity in a model of acute hepatocellular necrosis

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Yurdaydin C., Swain M., Mininberg E., Vergalla J., Kleiner D., Paul S., ...More

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, vol.10, no.6, pp.503-507, 1998 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 10 Issue: 6
• Publication Date: 1998
• Doi Number: 10.1097/00042737-199806000-00012
• Journal Name: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.503-507
• Keywords: hepatic encephalopathy, thioacetamide, polyamines, ornithine, ACUTE LIVER-FAILURE, HEPATIC-ENCEPHALOPATHY, RAT-LIVER, ALPHA-DIFLUOROMETHYLORNITHINE, POLYAMINE METABOLISM, ALCOHOLIC HEPATITIS, NITRIC-OXIDE, REGENERATION, AMINOTRANSFERASE, PUTRESCINE
• Ankara University Affiliated: No

Abstract

Objective The effect of blockade of the enzyme ornithine decarboxylase by difluoromethylornithine (DFMO) on hepatocellular necrosis and survival in rats treated with thioacetamide (TAA) was investigated.