Sarcoidosis caused by interferon therapy

ÇELİK G., Sen E., Ulger A., ÖZDEMİR KUMBASAR Ö., Bozkaya H., Alper D., ...Daha Fazla

RESPIROLOGY, cilt.10, sa.4, ss.535-540, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 4
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1111/j.1440-1843.2005.00746.x
  • Dergi Adı: RESPIROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.535-540
  • Anahtar Kelimeler: hepatitis C, interferon side-effects, interferon therapy, sarcoidosis, CHRONIC HEPATITIS-C, ALPHA THERAPY, CUTANEOUS SARCOIDOSIS, PULMONARY SARCOIDOSIS, ALVEOLAR MACROPHAGES, SYSTEMIC SARCOIDOSIS, VIRUS-INFECTION, RIBAVIRIN, PATIENT, INJURY
  • Ankara Üniversitesi Adresli: Evet

Özet

Interferon alpha (IFN-alpha) is an immunomodulator that is used as an antiviral agent in active chronic viral hepatitis C. IFN therapy can cause an induction or exacerbation of sarcoidosis. Although several reports in the gastroenterology literature have suggested an association between IFN therapy and sarcoidosis, this association has rarely been described elsewhere. A 47-year-old woman developed sarcoidosis after cessation of treatment with IFN and ribavirin for chronic hepatitis C. Her sarcoidosis showed liver, pulmonary and skin involvement. She continues to be monitored regularly in the Department of Pulmonary Diseases without steroid therapy. Her sarcoidosis improved spontaneously. We conclude that patients should be monitored for sarcoidosis during and after IFN therapy.