Influence of aluminum tristearate and sucrose stearate as the dispersing agents on physical properties and release characteristics of Eudragit RS microspheres

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Horoz B., KILIÇARSLAN M., YÜKSEL N., Baykara T.

AAPS PHARMSCITECH, cilt.7, sa.1, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 1
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1208/pt070116
  • Dergi Adı: AAPS PHARMSCITECH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: aluminum tristearate, sucrose stearate, Eudragit RS 100, solvent evaporation method, verapamil HCl, SOLVENT EVAPORATION METHOD, IN-VITRO RELEASE, POLY(LACTIDE-CO-GLYCOLIDE) MICROSPHERES, VERAPAMIL HYDROCHLORIDE, POLYMERIC MICROSPHERES, DRUG-RELEASE, PROTEIN, MICROENCAPSULATION, MICROCAPSULES, ENCAPSULATION
  • Ankara Üniversitesi Adresli: Evet

Özet

The purpose of this research was to investigate the effects of different concentrations of polymer and sucrose stearate, aluminum tristearate as dispersing agents on microsphere properties and performance. The yield values of microspheres were over the 78%, and the encapsulation efficiencies were found to be similar to 73%. Particle sizes of microspheres prepared with aluminum tristearate were between 76 and 448 mu m, while that of the microspheres containing sucrose stearate were between 521 and 2000 mu m. Morphological and physicochemical properties of microspheres were investigated by scanning electron micrography and differential scanning calorimetry (DSC). DSC analysis indicated that verapamil hydrochloride formed a solid solution with acrylic polymers. In vitro release studies were performed using the flow-through cell method. While similar to 80% of drug was released from the microspheres containing aluminum tristearate in 480 minutes, the same amount of drug was released from microspheres containing sucrose stearate in only 60 minutes. Chemical structures and concentrations of the dispersing agents were clearly effective on the physical properties of microspheres and their drug-release characteristics.