Akademik Veri Yönetim Sistemi
Turk Hijyen ve Deneysel Biyoloji Dergisi, cilt.76, sa.4, ss.473-486, 2019 (Scopus)
© 2019 Refik Saydam National Public Health Agency (RSNPHA).In order to find an effective solution to the treatment of cancer disease, many international collaborative researches have been carried out and many promising results have been obtained from these on going studies. An effective solution has not yet been found for cancer disease but studies on the development of new treatment methods and the findings of the research results continue to be published. In this context, in the studies focusing on the treatment of cancer, the findings obtained after the use of advanced technologies have been used in personalized medicine and clinical applications. Nowadays, next-generation sequencing technologies, which provide information on genomes with genome sequencing, are one of the most advanced technologies used in cancer research. Next-generation sequencing technology examines both genes and identifies some mutations. This technique enables the identification of unknown sequence variations in a short time and more easily, thus enabling clinicians to better understand the mechanisms of cancer. In this review, we aimed to provide information about the availability of next generation sequencing technology in pharmaceutical applications including areas such as tumor marker determination to pharmacogenomics, targeted therapy, precision medicine, vaccine treatment, biopharmaceutics, polypharmocology, toxgonostics and pharmacoepidemiology.