Effects of eccentric exercise on different slopes

Gokce E., AKAT F., Dursun A. D., GÜNEŞ E., Bayram P., BİLLUR D., ...More

JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS, vol.19, no.4, pp.412-421, 2019 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4
  • Publication Date: 2019
  • Journal Name: JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.412-421
  • Keywords: Creatine Kinase, Eccentric Exercise, HSP70, Muscular Damage, Small Animal Treadmill, ONSET MUSCLE SORENESS, HUMAN SKELETAL-MUSCLE, HEAT-SHOCK PROTEINS, DAMAGE, MECHANISMS, PAIN, CONTRACTIONS, ADAPTATION, STRESS, INJURY
  • Ankara University Affiliated: Yes

Abstract

Objectives: Eccentric contraction occurs when the muscle lengthens under tension. Damage-induced responses seen in the muscle after eccentric exercise usually experienced by sedentary individuals. This study aims to investigate muscle damage on different slopes. Methods: 32 male Wistar albino rats randomly divided into four groups: sedentary, horizontal running, and eccentric exercise (-8 degrees, -16 degrees) groups. Animals ran for 90 min with the speed of 25 m/s for five days. After 48h from the last exercise, rats were sacrificed, and plasma creatine kinase (CK), heat shock protein 70 (HSP70) levels were examined. Plasma and soleus total oxidant/antioxidant status (TOS-TAS) and histological changes of soleus muscle assessed. Results: CK and HSP70 significantly increased in 16 degrees EE group. TOS increased at 16 degrees EE and 8 degrees EE, but oxidative stress index (OSI) was only high at 8 degrees EE group. Mononuclear cell infiltration and the angiogenesis increased in soleus after eccentric exercise, and there was a correlation with slope. Sarcomere breaks were detected in 16 degrees EE group also in a correlation with slope. Conclusions: Consequently, sedentary individuals are vulnerable to injuries induced by eccentric contraction. Therefore, our study provides information for reconsidering rehabilitation and training programs.