New indole-7-aldehyde derivatives as melatonin analogues; synthesis and screening their antioxidant and anticancer potential

Shirinzadeh, Hanif; Neuhaus, Eddy; Erguc, Elif; Aliyev, Alev; GÜRER ORHAN, HANDE; SÜZEN, SİBEL

doi:10.1016/j.bioorg.2020.104219

New indole-7-aldehyde derivatives as melatonin analogues; synthesis and screening their antioxidant and anticancer potential

Shirinzadeh H., Neuhaus E., Erguc E. I., Aliyev A. T., GÜRER ORHAN H., SÜZEN S.

BIOORGANIC CHEMISTRY, cilt.104, 2020 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 104
Basım Tarihi: 2020
Doi Numarası: 10.1016/j.bioorg.2020.104219
Dergi Adı: BIOORGANIC CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
Anahtar Kelimeler: Indole, Melatonin, Synthesis, Antioxidant activity, Cytotoxicity, CYP1 inhibition, IN-VITRO ANTIOXIDANT, INDOLE-BASED ANALOGS, HYDRAZONE DERIVATIVES, SCAVENGING ACTIVITY, OXIDATIVE STRESS, DESIGN, ASSAYS, BEHAVIOR
Ankara Üniversitesi Adresli: Evet

Özet

Over the last decade, there has been substantial interest in the use of melatonin (MLT) and MLT-like compounds in the treatment of several diseases. MLT can scavenge different reactive oxygen species and can also stimulate the synthesis of antioxidant enzymes.