New indole-7-aldehyde derivatives as melatonin analogues; synthesis and screening their antioxidant and anticancer potential

Shirinzadeh, Hanif; Neuhaus, Eddy; Erguc, Elif; Aliyev, Alev; GÜRER ORHAN, HANDE; SÜZEN, SİBEL

doi:10.1016/j.bioorg.2020.104219

New indole-7-aldehyde derivatives as melatonin analogues; synthesis and screening their antioxidant and anticancer potential

Atıf İçin Kopyala

Shirinzadeh H., Neuhaus E., Erguc E. I., Aliyev A. T., GÜRER ORHAN H., SÜZEN S.

BIOORGANIC CHEMISTRY, cilt.104, 2020 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 104
Basım Tarihi: 2020
Doi Numarası: 10.1016/j.bioorg.2020.104219
Dergi Adı: BIOORGANIC CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
Anahtar Kelimeler: Indole, Melatonin, Synthesis, Antioxidant activity, Cytotoxicity, CYP1 inhibition, IN-VITRO ANTIOXIDANT, INDOLE-BASED ANALOGS, HYDRAZONE DERIVATIVES, SCAVENGING ACTIVITY, OXIDATIVE STRESS, DESIGN, ASSAYS, BEHAVIOR
Ankara Üniversitesi Adresli: Evet

Özet

Over the last decade, there has been substantial interest in the use of melatonin (MLT) and MLT-like compounds in the treatment of several diseases. MLT can scavenge different reactive oxygen species and can also stimulate the synthesis of antioxidant enzymes.