Conductimetric titrimetry for assay of selected antibiotics in non-aqueous media

Kilic E., Koseoglu F., KENAR A., Akay M. A.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, cilt.13, sa.12, ss.1453-1458, 1995 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 12
  • Basım Tarihi: 1995
  • Doi Numarası: 10.1016/0731-7085(95)01577-9
  • Dergi Adı: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1453-1458
  • Anahtar Kelimeler: ampicillin, amoxycillin trihydrate, rifampin, netilmicin sulphate, ciproflaxacin hydrochloride, conductimetric titration, acetic acid solvent, perchloric acid, barium acetate, titrimetric assay, TETRABUTYLAMMONIUM HYDROXIDE, SPECTROPHOTOMETRIC METHOD, TITRATIONS, ACIDS, ACETONITRILE, PENICILLINS, SOLVENTS, PYRIDINE
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study, a conductimetric titration method is proposed for the determination of some commonly used antibiotics. The conductimetric titration of three antibiotics, namely ampicillin, amoxycillin trihydrate and rifampin, was carried out in acetic acid using perchloric acid as titrant. Ciproflaxacin hydrochloride, however, was titrated after being dissolved in acetic acid containing an excess of mercury(II) acetate. For the titration of netilmicin sulphate, barium acetate prepared in acetic acid was used as titrant. The method was found to be highly accurate and precise, having a relative standard deviation of less than 1.0% for all antibiotics studied. It was also shown that the conductimetric titrimetry could be successfully applied to the assay of commercial preparations containing the above-mentioned antibiotics. The validity of the method was tested by the recovery studies of standard addition to pharmaceuticals and the results were found to be satisfactory.