Adsorptive stripping voltammetric determination of midazolam as a method for quality control

KIR S., Onar A., Temizer A.

Analytica Chimica Acta, vol.229, no.C, pp.145-147, 1990 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 229 Issue: C
  • Publication Date: 1990
  • Doi Number: 10.1016/s0003-2670(00)85120-x
  • Journal Name: Analytica Chimica Acta
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.145-147
  • Ankara University Affiliated: No

Abstract

Controlled interfacial accumulation of the benzodiazepine midazolam at a hanging mercury drop electrode provides the basis for a highly sensitive and accurate adsorptive stripping voltammetric procedure. The response was linear in the range 1.9 × 10-6- × 10-9 M when using a 120-s preconcentration at -0.45 V vs. Ag/AgCl in Britton-Robinson buffer of pH 5.00. In this range the relative standard deviation was between 1.21 and 1.62%. The applicability of the method to pharmaceutical preparations is discussed. © 1990.