The role of p53, Bcl-2 and Ki-67 in premalignant cervical lesions and cervical cancer

Tuerkcueoglu I., Tezcan S., Kaygusuz G., Atabekoglu C. S., Ortac F., Guengoer M., ...Daha Fazla

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, sa.4, ss.290-293, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2007
  • Dergi Adı: EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.290-293
  • Anahtar Kelimeler: cervical intraepithelial neoplasia, cervical cancer, p53, Bcl-2, Ki-67, SQUAMOUS-CELL CARCINOMA, INTRAEPITHELIAL NEOPLASIA, UTERINE CERVIX, EXPRESSION, PROTEIN, BAX, PROLIFERATION, APOPTOSIS, MUTATIONS, INDEX
  • Ankara Üniversitesi Adresli: Evet

Özet

Purpose: The aim of this study was to determine the role of p53, Bcl-2 and Ki-67 expression in the carcinogenesis of cervical carcinoma and aggressiveness of cervical intraepithelial neoplasia (CIN). Methods: The pathology specimens of 63 patients with a diagnosis of normal squamous epithelium (22 cases), CIN I (14), CIN II (5), CIN III (8) and squamous cell carcinoma (14) were evaluated immunohistochemically for the expression of p53, Bcl-2 and Ki-67 in paraffin sections. Results: The expression of p53 and Ki-67 increased proportionally to the grade of CIN and cervical cancer, but only the increase of p53 expression was statistically significant (p = 0.002). There was no significant correlation between Bcl-2 expression and premalignant and malignant cervical lesions. Conclusion: p53 expression may have a role in the carcinogenesis of squamous cell cervical carcinoma whereas Bcl-2 expression has no role. Ki-67 expression can not be used in determining the aggressiveness of CIN lesions.