Reactivities of mixed organozinc and mixed organocopper reagents, 2. Selective n-alkyl transfer in tri-n-butylphosphine-catalyzed acylation of n-alkyl phenylzincs; an atom economic synthesis of n-alkyl aryl ketones

Erdik, Ender; Pekel, ÖZGEN

doi:10.1016/j.tetlet.2009.01.082

Reactivities of mixed organozinc and mixed organocopper reagents, 2. Selective n-alkyl transfer in tri-n-butylphosphine-catalyzed acylation of n-alkyl phenylzincs; an atom economic synthesis of n-alkyl aryl ketones

Atıf İçin Kopyala

Erdik E., Pekel Ö.

Tetrahedron Letters, cilt.50, sa.13, ss.1501-1503, 2009 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 50 Sayı: 13
Basım Tarihi: 2009
Doi Numarası: 10.1016/j.tetlet.2009.01.082
Dergi Adı: Tetrahedron Letters
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1501-1503
Anahtar Kelimeler: Acylation, Alkyl arylzincs, Mixed diorganozincs, n-Alkyl aryl ketones, Tributylphosphine
Ankara Üniversitesi Adresli: Evet

Özet

Tri-n-butylphosphine-catalyzed acylation of mixed n-alkyl phenylzincs with aromatic acyl halides in THF is efficient in selective transfer of n-alkyl groups to produce n-alkyl aryl ketones in good yields. This route provides an atom economic organocatalyzed alternative to transition metal-catalyzed acylation of di-n-alkylzincs. © 2009 Elsevier Ltd. All rights reserved.