Reactivities of mixed organozinc and mixed organocopper reagents, 2. Selective <i>n</i>-alkyl transfer in tri-<i>n</i>-butylphosphine-catalyzed acylation of <i>n</i>-alkyl phenylzincs; an atom economic synthesis of <i>n</i>-alkyl aryl ketones

Erdik E., Pekel Ö.

TETRAHEDRON LETTERS, cilt.50, sa.13, ss.1501-1503, 2009 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 13
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.tetlet.2009.01.082
  • Dergi Adı: TETRAHEDRON LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Current Chemical Reactions (CCR)
  • Sayfa Sayıları: ss.1501-1503
  • Anahtar Kelimeler: Acylation, Alkyl arylzincs, Mixed diorganozincs, n-Alkyl aryl ketones, Tributylphosphine
  • Ankara Üniversitesi Adresli: Evet

Özet

Tri-n-butylphosphine-catalyzed acylation of mixed n alkyl phenylzincs with aromatic acyl halides in THF is efficient in selective transfer of n-alkyl groups to produce n-alkyl aryl ketones in good yields. This route provides an atom economic organocatalyzed alternative to transition metal-catalyzed acylation of di-n-alkylzincs. (C) 2009 Elsevier Ltd. All rights reserved.