Comparison of Spectral Domain Optical Coherence Tomography (SD OCT) Findings with Laser Flare Photometry (LFP) Measurements in Behcet's Uveitis
OCULAR IMMUNOLOGY AND INFLAMMATION, cilt.28, sa.2, ss.194-199, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 2
- Basım Tarihi: 2020
- Doi Numarası: 10.1080/09273948.2018.1552976
- Dergi Adı: OCULAR IMMUNOLOGY AND INFLAMMATION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.194-199
- Anahtar Kelimeler: flare, optical coherence tomography, choroidal thickness, active Behcet's uveitis, quiescent Behcet's uveitis, SUBFOVEAL CHOROIDAL THICKNESS, INTRAOCULAR INFLAMMATION, INDOCYANINE GREEN, CELL PHOTOMETRY, DISEASE, ANGIOGRAPHY, FLUORESCEIN
- Ankara Üniversitesi Adresli: Evet
Özet
Purpose: This study aims to compare the spectral domain optical coherence tomography (SD OCT) findings and laser flare photometry (LFP) measurements in Behcet's disease (BD).Methods: This study was composed of 4 groups as follows: "Group 1: Healthy volunteers, Group 2: Volunteers with BD and no eye involvement, Group 3: Patients with active uveitis with BD, Group 4: Patients with BD in quiescent phase of uveitis". Laser Flare Photometry (Kowa FM-600, Kowa Acculas, San Jose, CA, USA), SD-OCT and Enhanced Depth Imaging protocol (EDI) (Spectralis (R), Heidelberg Engineering Inc., Heidelberg, Germany) and Fundus Florescein Angiography (FFA) (Heidelberg Retina Angiograph 2 (R); Heidelberg Engineering, Heidelberg, Germany) were performed for all patients.Results: Twenty-four eyes of 12 healthy volunteers (Group 1); 61 eyes without ocular involvement of 31 volunteers with BD (Group 2); 29 active uveitic eyes of 17 patients with BD (Group 3); 35 eyes with quiescent uveitis in 18 patients with BD (Group 4) participated in the evaluation. There was a significant difference between visual acuity, submacular choroidal thickness (SCT), and flare values comparison among the groups(p<0.001,p<0.002, and p<0.001). When compared considering the SCT, choroidal thickness in Group 3 was higher than in the eyes of Group 1 and Group 2 (p:0.005, p:0.006). Central macular thickness (CMT) and disease duration were negatively correlated (rho:-0.453, p<0.001), while CMT and flare values were positively correlated (rho:0.267,p:0.006).Conclusion: Flare is a reliable indicator of the inflammation in Behcet's uveitis. Its concurrent use with OCT to evaluate choroid and macula enables the assessment of inflammation.