Decreased expression of beta(1)- and beta(2)-adrenoceptors in human diabetic atrial appendage

Dincer, U.; Guner, Sahika; Tay, Aydin; ARIOĞLU İNAN, EBRU; Tasdelen, Atilay; Aslamaci, Sait; Bidasee, Keshore

doi:10.1186/1475-2840-2-6

Decreased expression of beta(1)- and beta(2)-adrenoceptors in human diabetic atrial appendage

Dincer U. D., Guner S., Tay A., ARIOĞLU İNAN E., Tasdelen A., Aslamaci S., ...Daha Fazla

CARDIOVASCULAR DIABETOLOGY, cilt.2, 2003 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 2
Basım Tarihi: 2003
Doi Numarası: 10.1186/1475-2840-2-6
Dergi Adı: CARDIOVASCULAR DIABETOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Ankara Üniversitesi Adresli: Evet

Özet

Background: Using the streptozotocin-induced diabetic rat model, we have recently showed that the expression and function of beta(1)-adrenoreceptor were decreased in the diabetic rat heart. However, the effect of diabetes on expression of beta-adrenoreceptors in human cardiac tissue remains undefined. Therefore, the focus of the present study was to investigate the effect of diabetes on mRNA encoding beta(1)- and beta(2)-ARs in human atrial tissues.