Decreased expression of beta(1)- and beta(2)-adrenoceptors in human diabetic atrial appendage

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Dincer U. D., Guner S., Tay A., ARIOĞLU İNAN E., Tasdelen A., Aslamaci S., ...Daha Fazla

CARDIOVASCULAR DIABETOLOGY, cilt.2, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1186/1475-2840-2-6
  • Dergi Adı: CARDIOVASCULAR DIABETOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Using the streptozotocin-induced diabetic rat model, we have recently showed that the expression and function of beta(1)-adrenoreceptor were decreased in the diabetic rat heart. However, the effect of diabetes on expression of beta-adrenoreceptors in human cardiac tissue remains undefined. Therefore, the focus of the present study was to investigate the effect of diabetes on mRNA encoding beta(1)- and beta(2)-ARs in human atrial tissues.