Akademik Veri Yönetim Sistemi
KUWAIT MEDICAL JOURNAL, cilt.56, sa.4, ss.317-324, 2024 (SCI-Expanded, Scopus)
Objective: In coronary artery diseases and heart failure, platelet-hemoglobin ratio (PHR) has been proven to have a predictive value. We aim to study the relationship between PHR and contrast-induced nephropathy (CIN).
Design: Retrospective study
Setting: University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital
Subjects: A total of 1513 patients were included in the study. The patients were divided into two groups, those with and without CIN.
Interventions: Percutaneous coronary intervention and CIN
Main outcome measures: PHR, platelet count, hemoglobin, serum troponin, N-terminal proBNP (NT-proBNP), creatinine and 48-72 hours creatinine levels were assessed.
Results: CIN developed in 265 (17.5%). Atrial fibrillation (AF), diabetes mellitus, hypertension (HT), hyperlipidemia and heart failure are more common (P<0.001, P <0.001, P <0.001, P =0.043, P =0.008, respectively); and PHR (1.94 +/- 0.96 vs. 2.13 +/- 0.95, P =0.005), peak creatinine kinase-myocardial band (CK-MB), peak troponin and NT-proBNP were found to be higher; while hemoglobin values were found to be lower in CIN patients. Age, AF, HT, left ventricle ejection fraction, hemoglobin, peak CK-MB, peak troponin, NTproBNP and PHR were independent risk factors according to regression analysis (P=0.001, P <0.001, P <0.001, P =0.046, P =0.001, P =0.001, P =0.010, P =0.009, P =0.007, P <0.001, respectively). The receiver operating characteristic showed that the optimal PHR value for estimating the CIN was 1.86, with 66.1% sensitivity and 63.9% specificity (area under the curve: 0.686; 95% CI: 0.647-0.724, P <0.001).
Conclusions: A relationship has been found between PHR and CIN. PHR may provide more benefits than conventional blood markers in reckoning CIN.