Hereditary multiple exostoses and acute myeloid leukemia: An unusual association

Gozdasoglu S., Uysal Z., Kurekci A., Akarsu S., Ertem M., FİTOZ Ö. S., ...Daha Fazla

PEDIATRIC HEMATOLOGY AND ONCOLOGY, cilt.17, sa.8, ss.707-711, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 8
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1080/08880010050211439
  • Dergi Adı: PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.707-711
  • Anahtar Kelimeler: child, hereditary, leukemia, multiple exostoses, P53 GENE-MUTATIONS, EXT2 GENES
  • Ankara Üniversitesi Adresli: Evet

Özet

Hereditary multiple exostoses (HME) is an autosomal dominant disorder characterized by the presence of multiple exostoses. Three genetic loci have been identified, of which two (EXT1 and EXT2) have tumor suppressor activity. HME greatly increases the risk to develop sarcoma in the dysplastic tissue. The authors report an 8-year-old girl with HME, who developed acute myeloblastic leukemia.