Nature does it better: mimicking in vivo conditions to resolve in vitro production side effects
Frontiers in Veterinary Science, cilt.12, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Kısa Makale
- Cilt numarası: 12
- Basım Tarihi: 2025
- Doi Numarası: 10.3389/fvets.2025.1617740
- Dergi Adı: Frontiers in Veterinary Science
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
- Anahtar Kelimeler: 3D cell culture, embryos, extracellular vesicles, in vitro production IVP, large offspring syndrome, oviductal fluid
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Üniversitesi Adresli: Evet
Özet
Oviduct represents the original place of fertilisation and early embryo development in all the domestic animals. In past time it has been considered a mere channel but new reproductive biotechnology approaches suggested the need of structurally and functionally efficient oviductal environment for in vitro embryo production. Recreating the oviductal microenvironment in IVP systems represents a paradigm shift in reproductive biotechnology. By incorporating reproductive fluids and utilising advanced 3D culture models could be reduced adverse IVP outcomes, and bring assisted reproduction closer to its natural counterpart.