Akademik Veri Yönetim Sistemi
The 43rd FEBS Congress, Praha, Çek Cumhuriyeti, 7 - 12 Temmuz 2018
Sepsis is accompanied by physiological, pathological, biochemical abnormalities induced by infection and is a public
health problem. It is the leading cause of mortality. Septic shock is defined as the need for a vasopressor to keep the mean
arterial pressure above 65 mmHg and serum lactate level above 2 mmol / L (> 18 mg / dL) in the absence of
hypovolaemia.
SuPAR (soluble urokinasetype
plasminogen activator receptor) plays a role in the migration of cells such as monocytes,
macrophages from the circulation to the tissues.
In this study, the effects of SuPAR on sepsis and septic shock diagnosis and prognosis were evaluated by comparison with
the currently used CRP (Creactive
protein), PCT (procalcitonin), APACHE 2 score of sepsis and septic shock patients
enrolled in intensive care unit.
Statistical analysis was performed using the SPSS 21.0 program.
Categorical variables were compared with Pearson Chisquare,
Yates corrected Chisquare
and Fisher tests and
Continuous variables were compared with nonparametric tests (MannWhitney
U test and KruskalWallis
test) since did
not fit normal distribution. The relationship between variables was assessed using the Spearman Correlation Test. The
decisionmaking
characteristics of the variables were examined by ROC curve analysis.
In our study, serum SuPAR levels were significantly higher in patients with sepsis (n = 26) and septic shock (n = 23)
compared to healthy controls (n = 25)The serum SuPAR levels were similar in the survivors and nonsurvivors at the end
of the 7 day / 28 day followup
and in the intensive care unit. When all groups were taken into consideration, we
determined significant correlations between the levels of SuPAR and CRP, PCT. There was no correlation between
variables in patient groups.
Our findings suggest that SuPAR may be used to diagnose sepsis and septic shock, but not enough to discriminate
between sepsis septic shock and predict prognosis.