The effects of platelet activating factor and hyperbaric oxygenation on the isolated duodenal contractility

Yildirim G., KOÇ E., BAŞTUĞ M., Saran Y., Zaloǧlu N., FIÇICILAR H., ...Daha Fazla

Ondokuz Mayis Universitesi Tip Dergisi, cilt.18, sa.3, ss.185-191, 2001 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 3
  • Basım Tarihi: 2001
  • Dergi Adı: Ondokuz Mayis Universitesi Tip Dergisi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.185-191
  • Anahtar Kelimeler: Duodenum, Hyperbaric oxygenation, Oxidative stress, Platelet-activating factor, Smooth muscle contractility
  • Ankara Üniversitesi Adresli: Evet

Özet

Platelet-activating factor has potent effects on gastrointestinal tract, and oxidative stress appears to play a role in the pathogenesis of some gastrointestinal tract diseases. We aimed to investigate the effects of hyperbaric oxygenation on the duodenal contractility of rats pretreated with platelet-activating factor or isotonic sodium chloride solution. Rats were exposed to hyperbaric oxygenation following platelet-activating factor or isotonic sodium chloride solution administration. The isometric contractions of isolated duodenal segments were measured. We observed that acetylcholine-induced contractions were more effective in the platelet-activating factor pretreated group diltiazem inhibited the contractility, and the contractile responses decreased in calcium-free medium. Histologically, we observed that pretreatment with platelet-activating factor caused inflamatory changes, and exposure to hyperbaric oxygenation exaggerated these effects. These results support the hypothesis which assumes that platelet-activating factor acts via free radical production or via prostaglandin formation and/or directly by increasing the contractility of smooth muscle, and these effects are exaggerated by hyperbaric oxygenation.