Akademik Veri Yönetim Sistemi
International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation, cilt.28, sa.4, ss.371-4, 2005 (SCI-Expanded)
The objectives of this study were to investigate the effects of Hylan G-F 20 (Synvisc; Genzyme Biosurgery, Ridgefield, New Jersey, USA) injections on clinical and biomechanical gait characteristics of patients with knee osteoarthritis. The design was a before-after trial, set in the gait laboratory of the rehabilitation unit of a university hospital. Twelve patients participated with an average age (+/- SD) of 63.2 +/- 4.4 years, and Kellgren and Lawrence grade II or III knee osteoarthritis. The main outcome measures were the Western Ontario McMaster Universities Osteoarthritis Index, and time-distance, kinematic and kinetic parameters of gait. The intervention used was a single course of three bilateral intra-articular injections of 2 ml Hylan G-F 20. One week after the treatment, the pain subscore and total score of WOMAC decreased from 9.2 +/- 2.7 to 4.8 +/- 3.1 and from 42.1 +/- 15.2 to 37.9 +/- 13.5, respectively. There was improvement in sagittal plane excursions of the knee (from 40.2 +/- 8.1 to 43.3 +/- 8.5), in extensor and adductor moments (from 0.26 +/- 0.2 to 0.14 +/- 0.1 and from 0.45 +/- 0.1 to 0.41 +/- 0.1, respectively), and in scaled vertical forces (from 85.8 +/- 4.5 to 88.4 +/- 5.4). All these differences were statistically significant. In conclusion, intra-articular Hylan G-F 20 injections not only decrease pain in patients with knee osteoarthritis, but can alter the natural history of the disease by decreasing excessive loads in the knees.