Akademik Veri Yönetim Sistemi
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.50, sa.2, ss.443-456, 2026 (Scopus, TRDizin)
Objective: When the base pairs that make up human DNA were revealed with the Human Genome Project, it was determined that only 2-3% of the genome was translated into mRNA, and 10-18% encoded RNAs that helped protein synthesis. The remaining approximately 80-87% of the genome was called ‘Junk DNA’. Later, in studies conducted on this region called junk, RNAs that do not code for protein but are involved in post-transcriptional gene regulation were discovered. Non-coding RNAs (ncRNAs) have many functions, from catalysis of biological reactions to cellular defense, from developmental processes to cellular response. Studies have shown that long non-coding RNAs (lncRNAs) have key roles in the control of gene expression and cellular processes suchas development and differentiation. Studies have shown that disorders in lncRNAs play a role in the pathogenesis of many diseases such as cancers, neurodegenerative diseases, mitochondrial diseases, immunodeficiency diseases and cardiovascular diseases. According to studies, lncRNAs are seen as promising in drug development and design approaches with their capacity to be both therapeutic targets and biomarkers in new treatment approaches. lncRNAs are also thought to serve important functions in plant immunity and response to changes in the environment. Some lncRNAs have been shown to play a role in the control of tissue differentiation and development in plants, signal transduction, and responses to environmental factors such as abiotic and biotic stress. Result and Discussion: In this review, recent advances in the understanding of the regulatory functions of long non-coding RNAs on the biology of living organisms are discussed.