Akademik Veri Yönetim Sistemi
Diğer, ss.138, 2025
Numerous factors influence an individual's quality of life, with oral health being a critical determinant. Oral flora encompasses
hard and soft tissues, moisture sources, and approximately 1,000 microorganisms. Disruption of this microbial homeostasis
can result in infections, cavities, and even tooth loss. Traditional treatments for cavities include crowns, extractions, and root
canals. This study focuses on improving root canal treatments. In root canal procedures, the canals are filled with gutta-percha,
a thermoplastic material that, when heated, melts and fills the canal. Over time, however, gutta-percha may lose its volumetric
integrity, shrinking, and may harbor bacteria that resist disinfection, leading to secondary infections.This study investigates the
development of a protective coating on gutta-percha surfaces to prevent infections caused by Staphylococcus epidermidis.
Chlorhexidine (CHX), a well-established antimicrobial agent used in various forms for dental cleaning was selected for this
purpose. To broaden the antimicrobial spectrum, Triclosan (TCS), another well-known antimicrobial compound used in dental
care, was incorporated into the coating. Gutta-percha surfaces were coated with CHX and CHX-co-TCS thin films using the
Oxidative Chemical Vapor Deposition (oCVD) method. The coated surfaces were then incubated with S. epidermidis for 1, 3,
and 7 days to assess the antimicrobial activity of the thin films. Results showed bacterial inhibition ranging from 81% to 99%
on each incubation day, demonstrating effective antimicrobial activity. Additionally, zone of inhibition tests were conducted
to determine whether coatings could prevent bacterial growth. The results indicated even after 7 days, bacteria could be
effectively removed, confirming the successful antimicrobial activity of the coatings.