Antinociceptive and anti-inflammatory activities of Ballota inaequidens

SEVER YILMAZ B., Ozbek H., Citoglu G. S.

PHARMACEUTICAL BIOLOGY, cilt.44, sa.8, ss.636-641, 2006 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 8
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1080/13880200600897577
  • Dergi Adı: PHARMACEUTICAL BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.636-641
  • Anahtar Kelimeler: anti-inflammatory activity, antinociceptive activity, Ballota inaequidens, median lethal dose (LD50), TRADITIONAL MEDICINE, FOLK MEDICINE, FLAVONOIDS, SAXATILIS, EXTRACT, TURKEY, PLANTS, MICE
  • Ankara Üniversitesi Adresli: Evet

Özet

The water extract of Ballota inaequidens Hub.-Mor. & Patzak (Lamiaceae) was investigated for antinociceptive and anti-inflammatory activities in mice and rats. The tail-flick test, acetic acid-induced writhing test, and the carrageenan-induced rat paw edema test were used to determine these effects. Our findings show that Ballota inaequidens caused dose-related inhibition in the acetic acid-induced abdominal stretching in mice. The medium effective dose (ED50) value of Ballota inaequidens was found to be 85.38 mg/kg. Ballota inaequidens showed no significant changes in the nociceptive threshold of the tail-flick test but did show an inhibition of paw edema induced by carrageenan. The ED50 value of Ballota inaequidens was found to be 99.42 mg/kg. The current study reveals that the water extract of Ballota inaequidens possesses promising antinociceptive and anti-inflammatory activities.