Effects of gabapentin on carrageenan-induced inflammation, acute phase reactants and gastric mucus secretion in rats

KILIÇ F. S., AYDIN Ş., YILDIRIM C., DÖNERTAŞ B., ÖNER K. S., KAYGISIZ B.

EUROPEAN JOURNAL OF THERAPEUTICS, cilt.25, sa.1, ss.23-27, 2019 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5152/eurjther.2018.543
  • Dergi Adı: EUROPEAN JOURNAL OF THERAPEUTICS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.23-27
  • Anahtar Kelimeler: Anti-inflammatory effect, carrageenan-induced inflammation, cytokine levels gabapentin, gastric mucus, NEUROPATHIC PAIN, FORMALIN TEST, MODEL, AMITRIPTYLINE, ACID
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: Gabapentin (GBP), which was first developed as an anticonvulsant agent, has recently gained great attention considering its pain relieving and anti-inflammatory effects. The aim of the present study was to investigate the anti-inflammatory effect of GBP on carrageenan (CAR)-induced paw edema and its gastric side effects by determining gastric mucus secretion in rats.