Effects of gabapentin on carrageenan-induced inflammation, acute phase reactants and gastric mucus secretion in rats
EUROPEAN JOURNAL OF THERAPEUTICS, cilt.25, sa.1, ss.23-27, 2019 (ESCI, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 1
- Basım Tarihi: 2019
- Doi Numarası: 10.5152/eurjther.2018.543
- Dergi Adı: EUROPEAN JOURNAL OF THERAPEUTICS
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.23-27
- Anahtar Kelimeler: Anti-inflammatory effect, carrageenan-induced inflammation, cytokine levels gabapentin, gastric mucus, NEUROPATHIC PAIN, FORMALIN TEST, MODEL, AMITRIPTYLINE, ACID
- Ankara Üniversitesi Adresli: Hayır
Özet
Objective: Gabapentin (GBP), which was first developed as an anticonvulsant agent, has recently gained great attention considering its pain relieving and anti-inflammatory effects. The aim of the present study was to investigate the anti-inflammatory effect of GBP on carrageenan (CAR)-induced paw edema and its gastric side effects by determining gastric mucus secretion in rats.