Synthesis and antimicrobial activities of 5-fluoro-1,2,6-trisubstituted benzimidazole carboxamide and acetamide derivatives
ARCHIV DER PHARMAZIE, cilt.334, sa.11, ss.361-365, 2001 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 334 Sayı: 11
- Basım Tarihi: 2001
- Dergi Adı: ARCHIV DER PHARMAZIE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
- Sayfa Sayıları: ss.361-365
- Anahtar Kelimeler: benzimidazole carbamates, benzimidazole acetates, benzimidazole acetamides, 1H-benzimidazole derivatives, antifungal and antibacterial activity, ANTHELMINTIC BENZIMIDAZOLES, PNEUMOCYSTIS-CARINII, ALBENDAZOLE, INVITRO
- Ankara Üniversitesi Adresli: Evet
Özet
Some 5-fluoro-6-substitute-1H-benzimidazole-2-carbamates (12a-e), 5-fluoro-6-substituted 1H-benzimidazole-2-acetate (13a-e) and 2-acetamide (14a-f) derivatives, 2-acetamido-5-fluoro-6-(morpholin-4-yl)-1-propyl-1H-benzimidazole (15), and 1-cyclopropyl-2-ethyl-5-fluoro-6-(4-methylpiperazin-1-yl)-1H-benzimidazole (16) were synthesized, and their antimicrobial and antifungal activities evaluated. Compound 12c exhibited the best activity against Candida albicans.