Synthesis and antimicrobial activities of 5-fluoro-1,2,6-trisubstituted benzimidazole carboxamide and acetamide derivatives

Kus C., GÖKER A. H., Altanlar N.

ARCHIV DER PHARMAZIE, cilt.334, sa.11, ss.361-365, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 334 Sayı: 11
  • Basım Tarihi: 2001
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.361-365
  • Anahtar Kelimeler: benzimidazole carbamates, benzimidazole acetates, benzimidazole acetamides, 1H-benzimidazole derivatives, antifungal and antibacterial activity, ANTHELMINTIC BENZIMIDAZOLES, PNEUMOCYSTIS-CARINII, ALBENDAZOLE, INVITRO
  • Ankara Üniversitesi Adresli: Evet

Özet

Some 5-fluoro-6-substitute-1H-benzimidazole-2-carbamates (12a-e), 5-fluoro-6-substituted 1H-benzimidazole-2-acetate (13a-e) and 2-acetamide (14a-f) derivatives, 2-acetamido-5-fluoro-6-(morpholin-4-yl)-1-propyl-1H-benzimidazole (15), and 1-cyclopropyl-2-ethyl-5-fluoro-6-(4-methylpiperazin-1-yl)-1H-benzimidazole (16) were synthesized, and their antimicrobial and antifungal activities evaluated. Compound 12c exhibited the best activity against Candida albicans.