Quantitative Analysis of Irbesartan in Pharmaceuticals and Human Biological Fluids by Voltammetry

BOZAL PALABIYIK B., DOĞAN TOPAL B., USLU B., ÖZKAN S. A., Aboul-Enein H. Y.

ANALYTICAL LETTERS, cilt.42, sa.14, ss.2322-2338, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 14
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1080/00032710903137491
  • Dergi Adı: ANALYTICAL LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2322-2338
  • Anahtar Kelimeler: Drug analysis, hanging mercury drop electrode, human serum, irbesartan, voltammetry, II-RECEPTOR ANTAGONISTS, SOLID-PHASE EXTRACTION, HUMAN PLASMA, LIQUID-CHROMATOGRAPHY, HUMAN URINE, DERIVATIVE SPECTROPHOTOMETRY, ELECTRODES, DRUG, HYDROCHLOROTHIAZIDE, ELECTROOXIDATION
  • Ankara Üniversitesi Adresli: Evet

Özet

A differential pulse (DP) and square wave (SW) voltammetric techniques were developed for the determination of irbesartan. The electrochemical behavior of irbesartan was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV) at the hanging mercury drop electrode (HMDE). Different parameters were tested to optimize the conditions of the determination. It was found that in the range of 8 x 10(-6) -1 x 10(-4) M, the currents measured by both of methods presented a good linear property as a function of the concentration of irbesartan. In addition, validation parameters, such as reproducibility, sensitivity, and recovery were evaluated as well. The slope of the log Ip-log nu linear plot was 0.58 indicating the diffusion control for 0.5 M sulphuric acid without the need for separation or complex sample preparation, since there was no interference from the excipients and endogenous substances.