Prophylaxis with recombinant-activated factor VII (rFVIIa) for minimally invasive surgery in a patient with congenital factor VII deficiency: a case report with a single-low dose of rFVIIa

Yilmaz A. A., Yalcin S., Serdaroglu H., SÖNMEZER M., Uysalel A.

BLOOD COAGULATION & FIBRINOLYSIS, cilt.19, sa.7, ss.693-695, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 7
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1097/mbc.0b013e3282f544ff
  • Dergi Adı: BLOOD COAGULATION & FIBRINOLYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.693-695
  • Anahtar Kelimeler: congenital factor VII deficiency, minimally invasive surgical procedures, recombinant-activated factor VII, replacement therapy, EXTRACORPOREAL-CIRCULATION, CONTINUOUS-INFUSION, CARDIAC-SURGERY, THERAPY
  • Ankara Üniversitesi Adresli: Evet

Özet

Congenital factor VII deficiency is a rare autosomal-recessive disorder and surgery in patients with factor VII deficiency has been reported to be endangered by intraoperative or postoperative bleeding, unless a replacement therapy is used. In this paper, we report a successful prophylaxis with single and low dose rFVIIa (12.5 mu g kg(-1)) in a 22-year-old homozygote factor VII deficient patient who underwent laparoscopic gynecologic surgery. Minimally invasive surgeries, such as laparoscopic surgery, could be safely performed in patients with congenital factor VII using single and low dose rFVIIa combined with vigilant clinical observation and laboratory examination. Blood Coagul Fibrinolysis 19:693-695 (C) 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.