Association between the 5-HTTLPR polymorphism and response to citalopram in Turkish patients with major depressive disorder Major Depresif Bozukluğu Olan Türk Hastalarda 5-HTTLPR Polimorfizmin ve Sitalopram Yanıtı Arasındaki İlişkisi

Uckun Z., BASKAK B., Ozdemir H., Ozelkizil E. T., Devrimci Ozguven H., SÜZEN H. S.

Turkish Journal of Pharmaceutical Sciences, cilt.13, sa.2, ss.145-158, 2016 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5505/tjps.2016.29484
  • Dergi Adı: Turkish Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.145-158
  • Anahtar Kelimeler: 5-HTTLPR polymorphism, Citalopram, Side effects, Treatment response
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2016, Turkish Pharmacists Association. All rights reserved.The objective of this study was to investigate the relationship between the genetic polymorphism of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the response to citalopram treatment and side effects in Turkish patients with major depressive disorder. The study involved 51 patients who received 10-40 mg/day of citalopram for 4 to 6 weeks. Clinical symptoms were evaluated by the 17-item Hamilton Depression Rating (HAMD-17) scale, Clinical Global Impression (CGI) and UKU side effect rating scale (UKU) at weeks 4 and/or 6. The 5-HTTLPRL/S polymorphism was determined by slowdown-polymerase chain reaction method. Of the fifty-one patients, 13 (26%) were the LL genotype, 21 (41%) were the LS genotype, 17 (33%) were the SS genotype. L allele seems to be associated with better response due to odds ratio for L allele versus S allele despite statistically insignificant. In terms of CGI-Severity scale, The LL genotype versus the LS genotype had a higher risk at the week 6 (P<0.05). On the other hand, apart from this comparison, there is no significant difference in CGI-Severity and Improvement and UKU scales according to the distribution of genotypes at week 4 and/or 6. However, these findings surely need further investigation and confirmation.