Mixed chimerism following hematopoietic stem cell transplantation in pediatric thalassemia major patients: a single center experience

İNCE E., ERTEM M., İLERİ D. T., DALVA K., TOPÇUOĞLU P., Uysal Z.

TURKISH JOURNAL OF HEMATOLOGY, cilt.27, sa.1, ss.8-14, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 1
  • Basım Tarihi: 2010
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.8-14
  • Anahtar Kelimeler: Thalassemia major, mixed chimerism, pediatrics, chimerism, hematopoietic stem cell transplantation, non-malignant, BONE-MARROW-TRANSPLANTATION, BETA-THALASSEMIA, CHILDREN, GRAFT, RELAPSE, BLOOD
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: Stable mixed chimerism (MC) may result in cure for thalassemia major patients following hematopoetic stem cell transplantation (HSCT), but rejection can occur. Twenty-eight HSCTs for thalassemia major were reviewed retrospectively to evaluate the clinical course of MC with possible risk factors and predictors of outcome, with a median follow-up of 1669 days (811-3576 days).