Akademik Veri Yönetim Sistemi
SENSORS AND ACTUATORS B-CHEMICAL, cilt.420, 2024 (SCI-Expanded)
Herein, borazine (B3N3) 3 N 3 ) assisted-oriented surface imprinted electrochemical sensor was designed for umifenovir (UMI) detection in serum and urine samples. An imprinted electrochemical sensor was developed via photo- polymerization whereas butyl methacrylate monomer (BuMA) was selected as the functional monomer for coordinating the template molecules, UMI in the presence of B3N3 3 N 3 as orientating UMI molecules between polymeric phase and the electrode surface. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used to verify the electrochemical characterizations of the alterations at each step of the MIP production process. The created sensor was also characterized via contact angle, Fourier transform infrared spectrophotometry attenuated total reflection (FTIR-ATR), atomic force spectroscopy (AFM), and scanning electron microscopy (SEM) measurements. Furthermore, the electronic and molecular alterations on the electrode surface were assessed using quantum chemical calculations. Using differential pulse voltammetry (DPV) and EIS methods in standard solution and biological fluid samples, UMI was determined separately. The dynamic linear range of the designed sensor under optimized experimental conditions was found to be 0.50-7.50 pM and 0.25-5.00 pM for DPV and EIS methods, respectively. The developed sensor exhibited good recognition ability towards UMI molecules in the presence of its analogues as well as other interferents. As a result, the proposed sensors demonstrated excellent selectivity, high sensitivity, repeatability, and reproducibility performance for UMI analysis in commercial serum and urine samples.