Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia

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Gursoy-Ozdemir Y., Can A., Dalkara T.

STROKE, cilt.35, sa.6, ss.1449-1453, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 6
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1161/01.str.0000126044.83777.f4
  • Dergi Adı: STROKE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1449-1453
  • Anahtar Kelimeler: blood-brain barrier, matrix metalloproteinases, nitric oxide, peroxynitrite, reactive oxygen species, reperfusion injury, thrombolysis, NITRIC-OXIDE SYNTHASE, BLOOD-BRAIN-BARRIER, OXYGEN RADICALS, SUPEROXIDE, MICE, PEROXYNITRITE, GENERATION, INFARCTION, PROTECTS, MATRIX-METALLOPROTEINASE-9
  • Ankara Üniversitesi Adresli: Evet

Özet

Background and Purpose-Use of thrombolysis in stroke is limited by a short therapeutic window because delayed reperfusion may cause brain hemorrhage and edema. Available evidence suggests a role for superoxide, NO, and peroxynitrite in reperfusion-induced injury. However, depending on their cellular origin and interactions between them, these molecules may exert protective or deleterious actions, neither of which is characterized in the intact brain.