Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia
STROKE, vol.35, no.6, pp.1449-1453, 2004 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 35 Issue: 6
- Publication Date: 2004
- Doi Number: 10.1161/01.str.0000126044.83777.f4
- Journal Name: STROKE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1449-1453
- Keywords: blood-brain barrier, matrix metalloproteinases, nitric oxide, peroxynitrite, reactive oxygen species, reperfusion injury, thrombolysis, NITRIC-OXIDE SYNTHASE, BLOOD-BRAIN-BARRIER, OXYGEN RADICALS, SUPEROXIDE, MICE, PEROXYNITRITE, GENERATION, INFARCTION, PROTECTS, MATRIX-METALLOPROTEINASE-9
- Open Archive Collection: AVESIS Open Access Collection
- Ankara University Affiliated: Yes
Abstract
Background and Purpose-Use of thrombolysis in stroke is limited by a short therapeutic window because delayed reperfusion may cause brain hemorrhage and edema. Available evidence suggests a role for superoxide, NO, and peroxynitrite in reperfusion-induced injury. However, depending on their cellular origin and interactions between them, these molecules may exert protective or deleterious actions, neither of which is characterized in the intact brain.