Synthesis, Molecular Docking Studies and Antibacterial Activities of Novel Monocationic Indole-benzimidazole Derivatives

Ates-Alagoz Z., KIŞLA M. M., Goker H., Yildiz S.

MEDICINAL CHEMISTRY, cilt.17, sa.7, ss.699-706, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 7
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2174/1573406416666200420080459
  • Dergi Adı: MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.699-706
  • Anahtar Kelimeler: Synthesis, indoles, benzimidazolecarboxamides, antibacterial activities, molecular docking, pyruvate kinase, RESISTANT STAPHYLOCOCCUS-AUREUS, MRSA PYRUVATE-KINASE
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Finding efficient therapy against hospital-acquired MRSA infections has become rather important in the last decade. To this end, inhibition of the enzyme pyruvate kinase (PK) is being investigated for antibacterial activity, since this enzyme controls energy generation and metabolic flux distribution. Our main scaffold consists of benzimidazole and indole rings fused together. Both rings are famous for antibacterial properties and promising anti-MRSA compounds including indole ring.