De novo amyloidosis in a renal transplant patient

YILMAZ S., ÖZÇAKAR Z. B., BULUM AKBULUT B., KİREMİTCİ S., ENSARİ A., Ekim M., ...Daha Fazla

PEDIATRIC TRANSPLANTATION, cilt.18, sa.8, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 8
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1111/petr.12344
  • Dergi Adı: PEDIATRIC TRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: AA amyloidosis, proteinuria, renal allograft, denovo, kidney transplant, AA-AMYLOIDOSIS, SYSTEMIC AMYLOIDOSIS, ALLOGRAFT, INFECTIONS, SECONDARY, DISEASE
  • Ankara Üniversitesi Adresli: Evet

Özet

Systemic AA amyloidosis is a serious complication of many chronic inflammatory disorders and chronic infections. Renal involvement is seen in the majority of the patients and can lead to end-stage renal disease. Renal transplantation can be performed in these patients; however, amyloidosis can recur in the transplanted kidneys. On the other hand, de novo AA amyloidosis in renal transplant patients has been rarely reported. We report a 17-yr-old patient with end-stage renal disease due to genitourinary anomalies who developed recurrent pyelonephritis after transplantation. Three yr after transplantation, renal biopsy was performed for proteinuria and AA amyloidosis was identified in the renal allograft. Although rare, chronic infections might cause de novo amyloidosis in renal transplant patients. Therefore, amyloidosis should be kept in mind in those types of patients who present with proteinuria.