Atıf İçin Kopyala
PÜSKÜLLÜ M. O., Karaaslan C., BAKAR ATEŞ F., GÖKER A. H.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, cilt.51, sa.8, ss.723-733, 2015 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
51
Sayı:
8
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Basım Tarihi:
2015
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Doi Numarası:
10.1007/s10593-015-1765-7
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Dergi Adı:
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.723-733
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Anahtar Kelimeler:
carboxamidine, 3H-imidazo[4,5-b]pyridine, 3H-imidazo[4,5-c]pyridine, cytotoxicity, MCF-7 cell line, steric hindrance, TBK1/IKK-EPSILON KINASES, SELECTIVE INHIBITORS, AURORA KINASES, DNA-BINDING, AGENTS, BENZIMIDAZOLES, IDENTIFICATION, OPTIMIZATION, CHEMISTRY, DISCOVERY
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Ankara Üniversitesi Adresli:
Evet
Özet
A series of novel 2-phenyl-3H-imidazo[4,5-b]pyridines and 2-phenyl-3H-imidazo[4,5-c]pyridines and their precursors were synthesized. Their in vitro cytotoxicity against MCF-7 human breast adenocarcinoma cell line has been investigated, and some of the tested compounds have shown high cytotoxic activity against MCF-7 cells. N-Hydroxy-4-(3H-imidazo[4,5-b]pyridin-2-yl)benzenecarboximidamide was the most active compound with IC50 equal to 0.082 mu M, which is an activity almost as high as that of a commonly used anticancer drugs docetaxel and imatinib mesylate.