Early effects of mild brain trauma on the cytoskeletal proteins neurofilament(160) and MAP(2), and the preventive effects of mexilitine

Caner, H; Can, ALP; Atalay, B; Erdogan, B; Albayrak, AH; Kilinc, K; Bavbek, M; Altinors, N

doi:10.1007/s00701-003-0209-9

Early effects of mild brain trauma on the cytoskeletal proteins neurofilament(160) and MAP(2), and the preventive effects of mexilitine

Caner H., Can A., Atalay B., Erdogan B., Albayrak A., Kilinc K., ...More

ACTA NEUROCHIRURGICA, vol.146, no.6, pp.611-621, 2004 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 146 Issue: 6
Publication Date: 2004
Doi Number: 10.1007/s00701-003-0209-9
Journal Name: ACTA NEUROCHIRURGICA
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.611-621
Keywords: mild head injury, neurofilament protein (NF160), microtubule-associated protein-2 (MAP2), lipid peroxidation mexilitine, MICROTUBULE-ASSOCIATED PROTEINS, LIPID-PEROXIDATION, SPECTRIN PROTEOLYSIS, AXONAL INJURY, CALPAIN, MEXILETINE, EXPRESSION, ALPHA, PHASE, RISK
Ankara University Affiliated: Yes

Abstract

Objective. The aims were to investigate the early effects of graded, closed, mild head injury on neurofilament protein (NF160) and microtubule-associated protein-2 (MAP(2)) and to examine the levels of lipid peroxidation and the impact of mexilitine, inhibitor of lipid peroxidation, pretreatment on tissue damage.