Potential therapeutic value of transient receptor potential channels in male urogenital system

Toktanis G., KAYA SEZGİNER E., YILMAZ ORAL D., GÜR S.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, cilt.470, sa.11, ss.1583-1596, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 470 Sayı: 11
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1007/s00424-018-2188-y
  • Dergi Adı: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1583-1596
  • Anahtar Kelimeler: Erectile dysfunction, Lower urinary tract symptoms, Overactive bladder, Transient receptor potential channels, LOWER URINARY-TRACT, BLADDER-COOLING REFLEX, SMOOTH-MUSCLE-CELLS, TRP CHANNELS, ION-CHANNEL, VANILLOID RECEPTOR, CATION CHANNELS, GUINEA-PIG, INTRAVESICAL INSTILLATION, CRYOELECTRON MICROSCOPY
  • Ankara Üniversitesi Adresli: Evet

Özet

Transient receptor potential (TRP) channels comprise a family of cation channels implicated in a variety of cellular processes including light, mechanical or chemical stimuli, temperature, pH, or osmolarity. TRP channel proteins are a diverse family of proteins that are expressed in many tissues. We debated our recent knowledge about the expression, function, and regulation of TRP channels in the different parts of the male urogenital system in health and disease. Emerging evidence suggests that dysfunction ofTRP channels significantly contributes to the pathophysiology of urogenital diseases. So far, there are many efforts underway to determine if these channels can be used as drug targets to reverse declines in male urogenital function. Furthermore, developing safe and efficacious TRP channel modulators is warranted for male urogenital disorders in a clinical setting.