A research for some oxazolidinones to evaluate their antimicrobial activity Yeni oksazolidinonlarin antimikrobiyal aktivitelerini değerlendiren bir araştirma

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Atıf İçin Kopyala

KUŞ C., Ugurlu E., ALTANLAR N.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.42, sa.3, ss.32-37, 2018 (Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 42 Sayı: 3
• Basım Tarihi: 2018
• Doi Numarası: 10.1501/eczfak_0000000610
• Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
• Derginin Tarandığı İndeksler: Scopus
• Sayfa Sayıları: ss.32-37
• Anahtar Kelimeler: Antimicrobial activity, Linezolid, Oxazolidinon
• Ankara Üniversitesi Adresli: Evet

Özet

© 2018 University of Ankara. All rights reserved.Objectives: In this research, antimicrobial activity of some new oxazolidinone derivatives were evaluated against S. aureus ATCC 25923, E. coli ATCC 25922, B. subtilis ATCC 6633, methicillin-resistant Staphylococcus aureus (MRSA) clinical isolate and C. albicans ATCC 10231. Material and Method: Formerly obtained and published 10 oxazolidinones were tested against antimicrobial activity and this evaluation was carried out in Mueller-Hinton broth and Sabouraud dextrose broth. Result and Discussion: Compounds E5, and E9 showed antimicrobial activity against both bacteria and fungi with 25 µg/mL and 50 µg/mL, respectively. Our present research and the others have shown that the electro-negativity degree is very important for the biological activity.