MYCOSES, cilt.47, sa.7, ss.284-287, 2004 (SCI-Expanded)
The minimum inhibitory concentrations (MIC, mug ml(-1)) of itraconazole and terbinafine against overall 34 Aspergillus isolates from the external ear canals with otomycosis have been determined with M38-P microdilution method suggested by National Committee for Clinical Laboratory Standards (NCCLS). MIC intervals in 48 h determined by taking MIC-2 value of itraconazole (the lowest drug concentration causing 50% inhibition of visible fungal growth) and MIC-0 value of terbinafine (the lowest drug concentration causing 100% inhibition of visible fungal growth) as a basis have been found as follows: 0.125-1 and 0.06-0.5 mug ml(-1) for A. niger (22 strains), 0.06-0.25 and 0.06-0.125 mug ml(-1) for A. flavus (10 strains), 0.125 and 0.125-0.5 mug ml(-1) for A. terreus (two strains). It has been observed that both of the antifungal agents showed an in vitro activity against all Aspergillus species tested.