Genotype and Allele Frequency of CYP3A4-392A > G in Turkish Patients with Major Depressive Disorder

UÇKUN Z., BASKAK B., Ozdemir H., ÖZEL KIZIL E. T., ÖZGÜVEN H., SÜZEN H. S.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.15, sa.2, ss.200-206, 2018 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4274/tjps.46320
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.200-206
  • Anahtar Kelimeler: CYP3A4-392A > G, polymorphism, Turkish patients, major depressive disorder, PROSTATE-CANCER SUSCEPTIBILITY, GENETIC POLYMORPHISMS, CLINICAL PRESENTATION, AFRICAN-AMERICAN, CYP3A4-ASTERISK-1B POLYMORPHISM, CYP3A4, VARIANT, CYP2C19, ASSOCIATION, POPULATION
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives: Genetic polymorphisms may help for individualized drug dosing and improved therapeutics. CYP3A4 is responsible for the metabolism of more than 50% of the commonly used drugs and metabolizes typical antipsychotic medications and antidepressant drugs. The objective of the study was to assess the genotype and allele frequencies of CYP3A4 -392A>G in Turkish patients with major depressive disorder receiving any SSRIs and to compare these results with the frequencies of other ethnic groups.