Micronucleus levels and sister chromatide exchange frequencies in boron exposed and control individuals Bora maruz kalan bi̇reylerde ve kontrol bi̇reyleri̇nde mi̇kroçeki̇rdek düzeyleri̇ ve kardeş kromati̇d deǧi̇şi̇m frekanslari

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Uçkun Z., ÜSTÜNDAĞ A., Korkmaz M., DUYDU Y.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.38, sa.2, ss.79-88, 2009 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1501/eczfak_0000000518
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.79-88
  • Anahtar Kelimeler: Boron, Genotoxicity of boron, Lymphocytes, Micronucleus, Sister chromatide exchange
  • Ankara Üniversitesi Adresli: Evet

Özet

The aim of the study was to investigate the genotoxic effects in boron exposed humans. SCE frequencies in boron exposed and control group were 7,28 ± 1,60 and 9,50 ± 1,83, respectively. SCE frequencies in boron exposed individuals were significantly lower than the controls (Mann Whitney U- test, p<0,05). The MN values in boron exposed individuals were also lower than the control group. Nevertheless the difference between boron exposed humans and controls was statistically not significant (χ2 test, p>0,05). In spite of the statistical insignificancy, lower MN values were also observed in boron exposed group. When these results were taken into consideration the decrease in SCE and MN values might be a reflection of a protective effect of boron agonist DNA damage. However this suggestion surely needs further investigation.