ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation

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Rostami K., Marsh M. N., Johnson M. W., Mohaghegh H., Heal C., Holmes G., ...Daha Fazla

GUT, cilt.66, sa.12, ss.2080-2086, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 66 Sayı: 12
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1136/gutjnl-2017-314297
  • Dergi Adı: GUT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2080-2086
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives Counting intraepithelial lymphocytes (IEL) is central to the histological diagnosis of coeliac disease (CD), but no definitive 'normal' IEL range has ever been published. In this multicentre study, receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off between normal and CD (Marsh III lesion) duodenal mucosa, based on IEL counts on >400 mucosal biopsy specimens.