Factor V 1691 G-A mutation in children with intracardiac thrombosis: a prospective study

Atalay S., Akar N., Tutar H., YILMAZ E.

ACTA PAEDIATRICA, cilt.91, sa.2, ss.168-171, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 91 Sayı: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1080/080352502317285162
  • Dergi Adı: ACTA PAEDIATRICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.168-171
  • Anahtar Kelimeler: intracardiac thrombus, FVL mutation, prothrombin 20210 G-A mutation, ACTIVATED PROTEIN-C, POOR ANTICOAGULANT RESPONSE, VENOUS THROMBOSIS, VENTRICULOATRIAL SHUNT, TURKISH POPULATION, PROTHROMBIN GENE, LEIDEN, DEFICIENCY, RESISTANCE, INFANTS
  • Ankara Üniversitesi Adresli: Hayır

Özet

The objective of this study was to determine the association between intracardiac thrombosis and hereditary causes of thrombophilia, including factor V 1691 G-A (factor V Leiden, FVL) and prothrombin 20210 G-A mutations. Over a period of 3 y, genetic risk factors were evaluated in 13 consecutive children (mean age 6.27 5 44 y) with intracardiac thrombosis, diagnosed by, cross-sectional echocardiography. Thrombi were localized in the left heart in four patients and the right heart in nine patients. All children had predisposing factors for thrombus formation: ventriculoatrial shunt for hydrocephalus (n = 3), indwelling catheter for chemotherapy (n = 5), cardiomyopathy (n = 2), sepsis (n = 1), homocystinuria (n = 1) and tetralogy of Fallot (n = 1). Six of the 13 children with intracardiac thrombosis were heterozygotes for FVL mutation. Three of these six children with FVL mutation had ventriculoatrial shunt for hydrocephalus, two children had cardiomyopathy and one had sepsis. None of the patients carried the prothrombin 20210 G-A mutation.