A guide to adhesion GPCR research

Liebscher I., CEVHEROĞLU O., Hsiao C., Maia A. F., Schihada H., Scholz N., ...Daha Fazla

FEBS Journal, cilt.289, sa.24, ss.7610-7630, 2022 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 289 Sayı: 24
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1111/febs.16258
  • Dergi Adı: FEBS Journal
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.7610-7630
  • Anahtar Kelimeler: Adhesion GPCRs, clinical application, physiology, signaling, structure-function, PROTEIN-COUPLED-RECEPTOR, NEURAL-TUBE DEFECTS, MEMORY T-CELLS, STRUCTURAL BASIS, INHIBITORY RECEPTOR, TETHERED AGONIST, GPR56 ADGRG1, ANGIOGENESIS, CD97, GENE
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical SocietiesAdhesion G protein-coupled receptors (aGPCRs) are a class of structurally and functionally highly intriguing cell surface receptors with essential functions in health and disease. Thus, they display a vastly unexploited pharmacological potential. Our current understanding of the physiological functions and signaling mechanisms of aGPCRs form the basis for elucidating further molecular aspects. Combining these with novel tools and methodologies from different fields tailored for studying these unusual receptors yields a powerful potential for pushing aGPCR research from singular approaches toward building up an in-depth knowledge that will facilitate its translation to applied science. In this review, we summarize the state-of-the-art knowledge on aGPCRs in respect to structure–function relations, physiology, and clinical aspects, as well as the latest advances in the field. We highlight the upcoming most pressing topics in aGPCR research and identify strategies to tackle them. Furthermore, we discuss approaches how to promote, stimulate, and translate research on aGPCRs ‘from bench to bedside’ in the future.