Effects of black grape extract on activities of dna turn-over enzymes in cancerous and non cancerous human colon tissues

Durak I., Cetin R., Devrim E., Erguder I.

LIFE SCIENCES, cilt.76, sa.25, ss.2995-3000, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 76 Sayı: 25
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.lfs.2004.11.018
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2995-3000
  • Anahtar Kelimeler: cancer, adenosine deaminase, 5 ' nucleotidase, xanthine oxidase, black grape, CARCINOMA DU145 CELLS, ADENOSINE-DEAMINASE, SEED EXTRACT, SUPEROXIDE-DISMUTASE, CATALASE ACTIVITIES, XANTHINE-OXIDASE, APOPTOTIC DEATH, RESVERATROL, PROANTHOCYANIDINS, 5'-NUCLEOTIDASE
  • Ankara Üniversitesi Adresli: Evet

Özet

Effects of extract of dried whole black grape including seed on adenosine deaminase (ADA), 5' nucleotidase (5'NT) and xanthine oxidase (XO) enzymes were investigated in cancerous and non-cancerous human colon tissues. Enzyme activities were measured in 20 colon tissues, 10 from cancerous region and 10 from non cancerous region with and without pre incubation with black grape extract. ADA and 5' NT activities were found increased and that of the XO decreased in the cancerous tissues relative to non cancerous ones. After incubation period with black gape extract for 12 h, ADA and 5' NT activities were found to be significantly lowered but that of XO unchanged in both cancerous and non cancerous tissues.