Akademik Veri Yönetim Sistemi
REVISTA DE CHIMIE, cilt.56, sa.9, ss.937-942, 2005 (SCI-Expanded)
The bivariate and multivariate spectral resolutions of a mixture of benazepril hydrochloride and hydrochlorothiazide in tablets were carried out by using linear regression lines. In the first case, the bivariate spectral calibration (BSC) was obtained by using four linear regression lines with two single-component regressions for each compound at a two-wavelength set (242 and 272 nm). In the second case, the multivariate spectral calibration (MSC) was established by the simultaneous use of 16 linear regression lines with 16 single-component regression for each compound at a 16-wavelength set from 230 nm to 272 nm with the intervals of Delta lambda=3 nm for two compounds. The BSC and MSC calibration algorithms were briefly described for the two-component mixture system. All the methods were validated by analysing the synthetic mixture of two active compounds and applied to two commercial tablet formulations containing BE and HCT. The BSC and MSC methods, which are very rapid, easy to apply, yet not expensive, are powerful tools with very simple mathematical contents for quantitative analysis of the two-component or binary mixture systems. The obtained results were successfully compared with each other as well as with those obtained by other literature methods.