Association between plasma asymmetrical dimethylarginine activity and severity of aortic valve stenosis

Cagirci G., Cay S., Canga A., Karakurt O., YAZIHAN N., Kilic H., ...Daha Fazla

JOURNAL OF CARDIOVASCULAR MEDICINE, cilt.12, sa.2, ss.96-101, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.2459/jcm.0b013e32833cdcea
  • Dergi Adı: JOURNAL OF CARDIOVASCULAR MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.96-101
  • Anahtar Kelimeler: asymmetrical dimethylarginine, aortic valve stenosis, endothelial dysfunction, CORONARY-ARTERY-DISEASE, LOW-DENSITY-LIPOPROTEIN, NITRIC-OXIDE, ENDOTHELIAL DYSFUNCTION, EARLY LESION, RISK-FACTOR, ADMA, HYPERTENSION, PROGRESSION, EXPRESSION
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives Aortic valve stenosis is the most common valvular heart disease in the Western world. The most common cause of aortic valve stenosis in adults is calcification of a normal trileaflet or congenital bicuspid valve. Calcific aortic valve stenosis is an active disease process characterized by mechanical stress, endothelial damage, lipid accumulation, inflammation, synthesis of extracellular matrix proteins, and calcification, reminiscent of atherosclerosis in many aspects. Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase which reduces the bioavailability of nitric oxide and begets endothelial dysfunction. The goal of this study was to examine the association between ADMA activity and severity of aortic valve stenosis.